GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs1077514 | 1 | rs534417 | chr1:23784965 | TCEA3 | chr1:23707555-23751261:- | 0.23 | 4.33 | 1.82E-5 | Cholesterol, total |
| THCA | cis | rs672203 | 1 | rs535112 | chr1:70889476 | ZRANB2 | chr1:71528975-71546745:- | 0.11 | 3.39 | 0.000759 | Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) |
| THCA | cis | rs477692 | 1 | rs538969 | chr10:131410608 | MGMT | chr10:131265454-131565783:+ | 0.38 | 11.44 | 6.2E-27 | Response to temozolomide |
| THCA | cis | rs670523 | 1 | rs539602 | chr1:155899020 | FDPS | chr1:155278539-155290457:+ | -0.21 | -4.26 | 2.51E-5 | Crohn's disease;Inflammatory bowel disease |
| THCA | cis | rs670523 | 1 | rs539602 | chr1:155899020 | RIT1 | chr1:155867601-155881177:- | 0.17 | 3.9 | 0.000112 | Crohn's disease;Inflammatory bowel disease |
| THCA | cis | rs7116495 | 1 | rs541022 | chr11:71783056 | FAM86C | chr11:71498557-71512276:+ | 0.29 | 3.66 | 0.000278 | Severe influenza A (H1N1) infection |
| THCA | cis | rs614226 | 1 | rs541126 | chr12:120972396 | COQ5 | chr12:120941083-120966964:- | -0.15 | -3.69 | 0.000254 | Type 1 diabetes nephropathy |
| THCA | cis | rs614226 | 1 | rs541126 | chr12:120972396 | POP5 | chr12:121016849-121019201:- | 0.16 | 4.94 | 1.08E-6 | Type 1 diabetes nephropathy |
| THCA | cis | rs614226 | 1 | rs541126 | chr12:120972396 | RNF10 | chr12:120972132-121015396:+ | -0.22 | -3.66 | 0.000282 | Type 1 diabetes nephropathy |
| THCA | cis | rs7116495 | 1 | rs542752 | chr11:71810644 | FAM86C | chr11:71498557-71512276:+ | -0.32 | -3.89 | 0.000113 | Severe influenza A (H1N1) infection |
| THCA | cis | rs11880706 | 1 | rs543030 | chr19:6081667 | RFX2 | chr19:5993176-6110664:- | 0.35 | 3.75 | 0.000199 | Bipolar disorder and schizophrenia |
| THCA | cis | rs9420 | 1 | rs543725 | chr11:57483039 | MED19 | chr11:57471182-57479673:- | -0.21 | -4.47 | 9.71E-6 | Schizophrenia |
| THCA | cis | rs9420 | 1 | rs543725 | chr11:57483039 | TIMM10 | chr11:57295936-57298232:- | -0.26 | -6.36 | 4.61E-10 | Schizophrenia |
| THCA | cis | rs546131 | 1 | rs546131 | chr11:34851760 | PDHX | chr11:34937677-35017674:+ | -0.17 | -4.4 | 1.32E-5 | Lung disease severity in cystic fibrosis |
| THCA | cis | rs7116495 | 1 | rs548127 | chr11:71575294 | FAM86C | chr11:71498557-71512276:+ | 0.34 | 4.15 | 4.0E-5 | Severe influenza A (H1N1) infection |